产品货号:
Z34862
中文名称:
Ms CD11a/Integrin Alpha L/ITGAL Purified抗体
英文名称:
Anti-Ms CD11a/Integrin Alpha L/ITGAL Purified Antibody (Clone#M17/4)
产品规格:
0.1mg(C100)
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-Ms CD11a/Integrin Alpha L/ITGAL Purified Antibody (Clone#M17/4) |
指标别名 | CD11A;Integrin alpha L;ITGAL;LFA 1;LFA 1A;LFA1A |
克隆性 | Monoclonal |
检验物种 | mouse |
应用范围 | FCM,IP,IHC-F |
基因名称 | ITGAL |
克隆号 | M17/4 |
抗体来源 | Rat |
抗体类型 | IgG2a |
免疫原 | C57BL/6 mouse splenic secondary cytotoxic T lymphocytes.The rat monoclonal antibody M17/4 reacts with an extracellular epitope of CD11a (alpha-subunit of murine LFA-1),a 180kDa type I transmembrane glycoprotein expressed on B and T lymphocytes,monocytes,macrophages,neutrophils,basophils and eosinophils. |
成分 | Phosphate buffered saline (PBS),pH7.4,15mM sodium azide |
纯化方式 | Purified by protein-G affinity chromatography. |
浓度 | 1mg/mL |
产品形态 | 溶液 |
保存条件 | Store at 2~8℃.Do not freeze. |
背景资料 | CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1),the alphaLbeta2 integrin.CD11a is implicated in activation of LFA-1 complex.LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation.Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation,which supports tight binding of LFA-1 to its ligands,the intercellular adhesion molecules ICAM-1,-2,-3.LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement,but participates also in control of cell differentiation and proliferation and of T-cell effector functions.Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases.For example,humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation;binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity. |
Uniprot ID | E9Q5M7 |
基因名全称 | Integrin subunit alpha L |
推荐稀释比 | Flow cytometry:1μg/mL. Immunohistochemistry (frozen sections):Positive tissue:murine spleen or thymus,acetone fixation. |
相关搜索:Ms CD11a/Integrin Alpha L/ITGAL Purified抗体,Ms CD11a抗体,Integrin Alpha L抗体,ITGAL Purified单抗